Andreas Fregin Selected Research

Type 2 Combined Deficiency Of Vitamin K-Dependent Clotting Factors

10/2005	Site-directed mutagenesis of coumarin-type anticoagulant-sensitive VKORC1: evidence that highly conserved amino acids define structural requirements for enzymatic activity and inhibition by warfarin.
2/2004	Mutations in VKORC1 cause warfarin resistance and multiple coagulation factor deficiency type 2.

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Andreas Fregin Research Topics

Disease

4	Hemorrhage 09/2007 - 11/2002
3	Coumarin Resistance 02/2014 - 02/2004
2	Type 2 Combined Deficiency Of Vitamin K-Dependent Clotting Factors 10/2005 - 02/2004
1	1 Combined Deficiency Of Vitamin K-Dependent Clotting Factors 08/2004

Drug/Important Bio-Agent (IBA)

5	Blood Coagulation Factors (Coagulation Factor)IBA 09/2006 - 11/2002
3	Vitamin K FDA Link 09/2006 - 02/2004
2	AnticoagulantsIBA 02/2014 - 02/2004
2	Warfarin (Coumadin)FDA LinkGeneric 02/2014 - 02/2004
2	glutamyl carboxylase (gamma-glutamyl carboxylase)IBA 09/2006 - 08/2004
2	Protein CIBA 08/2004 - 11/2002
1	Dithiothreitol (Cleland's Reagent)IBA 02/2014
1	EnzymesIBA 02/2014
1	Factor IX (Coagulation Factor IX)FDA LinkGeneric 02/2014
1	Proteins (Proteins, Gene)FDA Link 02/2014
1	Pharmaceutical PreparationsIBA 09/2007
1	CoumarinsIBA 09/2007
1	Vitamin K Epoxide ReductasesIBA 09/2006
1	Cysteine (L-Cysteine)FDA Link 10/2005
1	plasma protein Z (protein Z)IBA 08/2004
1	coumarinIBA 02/2004
1	Protein SIBA 11/2002